Characterization of the neuropathic pain component contributing to myalgia in patients with myotonic dystrophy type 1 and 2.

ABSTRACT:

Introduction

Chronic muscle pain is common in myotonic dystrophies (DM). Little is known about its pathophysiology. We aimed to investigate the characteristics of the neuropathic pain component contributing contributes to the pathogenesis of chronic pain in DM.

Methods

Twenty-one DM1 and 32 DM2 patients completed pain questionnaires (Brief pain inventory-BPI, PAIN-DETECT, pain disability index-PDI) and underwent neurological examination, nerve conduction studies (NCS), quantitative sensory testing (QST, dorsum of the right hand and right thigh) and skin biopsy to determine the intraepidermal nerve fiber density (IENFD, distal and proximal site of lower extremity). NCS and QST results at the thigh were compared to 27 healthy controls and IENFD and QST at the dorsum of the han

SUBMITTER: Schmitt V 

PROVIDER: S-EPMC11347447 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature