Circulating inflammatory cytokines and sarcopenia-related traits: a mendelian randomization analysis.

ABSTRACT:

Objective

To explore the causal relationships between 91 circulating inflammatory cytokines and sarcopenia-related traits (low hand grip strength, appendicular lean mass, and usual walking pace) by Mendelian randomized analysis.

Methods

Independent genetic variations of inflammatory cytokines and sarcopenia-related traits were selected as instrumental variables from publicly available genome-wide association studies (GWAS). The MR analysis was primarily conducted using the inverse variance-weighted (IVW) method. Sensitivity analyses included Steiger filtering and MR PRESSO, with additional assessments for heterogeneity and pleiotropy.

Results

The IVW method indicated a causal relationship between Vascular Endothelial Growth Factor A (VEGF-A) and low hand grip strength

SUBMITTER: Sun A 

PROVIDER: S-EPMC11347448 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature