Assessing the steroid-sparing effect of biological agents in randomized controlled trials for lupus: a scoping review.

ABSTRACT: Prompt disease control of flares in patients with systemic lupus erythematosus (SLE) is a priority in treatment strategy planning. However, the long-term dosage-related collateral effects of glucocorticoids (GCs) have pushed researchers towards the identification and utilization of novel biological agents that could both induce and maintain low disease activity and remission, especially in the context of lupus nephritis (LN). This scoping review aims at assessing the current evidence of the potential steroid-sparing effect of biologic therapies by reviewing phase II and phase III randomized, placebo-controlled trials involving SLE/LN patients. A scoping review of the literature was carried out in accordance with PRISMA-ScR recommendations. Risk of bias was assessed through the utilization

SUBMITTER: Sciascia S 

PROVIDER: S-EPMC11347485 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature