Modelling the effectiveness of an isolation strategy for managing mpox outbreaks with variable infectiousness profiles.

ABSTRACT: The global outbreak of mpox in 2022 and subsequent sporadic outbreaks in 2023 highlighted the importance of nonpharmaceutical interventions such as case isolation. Individual variations in viral shedding dynamics may lead to either premature ending of isolation for infectious individuals, or unnecessarily prolonged isolation for those who are no longer infectious. Here, we developed a modeling framework to characterize heterogeneous mpox infectiousness profiles - specifically, when infected individuals cease to be infectious - based on viral load data. We examined the potential effectiveness of three different isolation rules: a symptom-based rule (the current guideline in many countries) and rules permitting individuals to stop isolating after either a fixed duration or following tests th

SUBMITTER: Jeong YD 

PROVIDER: S-EPMC11347573 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature