Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis.

ABSTRACT: High myopia (HM) is a leading cause of blindness worldwide with currently no effective interventions available. A major hurdle lies in its often isolated perception as a purely ocular morbidity, disregarding potential systemic implications. Recent evidence suggests the existence of a gut-eye axis; however, the role of gut microbiota in the pathogenesis of HM remains largely unexplored. Herein, we provide a potential crosstalk among HM's gut dysbiosis, microbial metabolites, and scleral remodeling. Utilizing 16S rRNA gene sequencing, we observed an altered gut microbiota profile in HM patients with a significant reduction in probiotic abundance compared with healthy controls. Subsequent targeted metabolic profiling revealed a notable decrease in plasma levels of the gut microbiota-derived m

SUBMITTER: Li H 

PROVIDER: S-EPMC11347609 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature