Deciphering simplified regional anticoagulation with citrate in intermittent hemodialysis: a clinical and computational study.

ABSTRACT: Regional citrate anticoagulation use in intermittent hemodialysis is limited by the increased risk of metabolic complications due to faster solute exchanges than with continuous renal replacement therapies. Several simplifications have been proposed. The objective of this study was to validate a mathematical model of hemodialysis anticoagulated with citrate that was then used to evaluate different prescription scenarios on anticoagulant effectiveness (free calcium concentration in dialysis filter) and calcium balance. A study was conducted in hemodialyzed patients with a citrate infusion into the arterial line and a 1.25 mmol/L calcium dialysate. Calcium and citrate concentrations were measured upstream and downstream of the citrate infusion site and in the venous line. The values measured

SUBMITTER: Aniort J 

PROVIDER: S-EPMC11347690 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature