Association of hyperfibrinolysis with poor prognosis in refractory circulatory arrest: implications for extracorporeal cardiopulmonary resuscitation.

ABSTRACT:

Background

Identifying candidates for extracorporeal cardiopulmonary resuscitation (eCPR) is challenging, and novel predictive markers are urgently needed. Hyperfibrinolysis is linked to tissue hypoxia and is associated with poor outcomes in out-of-hospital cardiac arrest (OHCA). Rotational thromboelastometry (ROTEM) can detect or rule out hyperfibrinolysis, and could, therefore, provide decision support for initiation of eCPR. We explored early detection of hyperfibrinolysis in patients with refractory OHCA referred for eCPR.

Methods

We analysed ROTEM results and resuscitation parameters of 57 adult patients with ongoing OHCA who presented to our ICU for eCPR evaluation.

Results

Hyperfibrinolysis, defined as maximum lysis ≥15%, was present in 36 patients (63%) and wa

SUBMITTER: Magomedov A 

PROVIDER: S-EPMC11347786 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature