Zinc Deficiency And sTNF-RII Are Associated With Worse COVID-19 Outcomes.

ABSTRACT:

Background

Zinc (Zn) is known for its substantial involvement in the immune response as an antioxidant and anti-inflammatory agent. Zn plasma levels' clinical significance in coronavirus disease (COVID) diagnosis is not yet fully established.

Objective

We assessed the association between Zn deficiency, gut integrity, inflammation, and COVID-19 outcomes.

Methods

A prospective observational cohort in which plasma Zn, soluble tumor necrosis factor alpha receptor II (sTNF-RII) intestinal fatty-acid binding protein (IFABP; marker of intestinal integrity), and zonulin levels (intestinal permeability) were collected from participants during the acute phase of a confirmed COVID-19 diagnosis. Zn was modeled as continuous and binary, categorized as Zn deficiency (Zn < 75 μg/dL)

SUBMITTER: Mouchati C 

PROVIDER: S-EPMC11347801 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature