Effect of cocoa extract supplementation on cognitive function: results from the clinic subcohort of the COSMOS trial.

ABSTRACT:

Background

Some prior randomized clinical trials (RCTs) that tested the effects of cocoa extract (CE), a source of flavanols, on late-life cognition have yielded promising findings. A long-term RCT using in-person neuropsychological tests covering multiple cognitive domains may clarify the cognitive effects of CE.

Objectives

To test whether daily supplementation with CE, compared with placebo, produces better cognitive change over 2 y.

Methods

The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is a 2 × 2 factorial RCT of CE [500 mg flavanols/d, including 80 mg (-)-epicatechin] and/or a daily multivitamin-mineral supplement for cardiovascular disease and cancer prevention among 21,442 United States adults aged ≥60 y. There were 573 participants in the clinic

SUBMITTER: Vyas CM 

PROVIDER: S-EPMC11347806 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature