Plasma lipidomic markers of diet quality are associated with incident coronary heart disease in American Indian adults: the Strong Heart Family Study.

ABSTRACT:

Background

Identifying lipidomic markers of diet quality is needed to inform the development of biomarkers of diet, and to understand the mechanisms driving the diet- coronary heart disease (CHD) association.

Objectives

This study aimed to identify lipidomic markers of diet quality and examine whether these lipids are associated with incident CHD.

Methods

Using liquid chromatography-mass spectrometry, we measured 1542 lipid species from 1694 American Indian adults (aged 18-75 years, 62% female) in the Strong Heart Family Study. Participants were followed up for development of CHD through 2020. Information on the past year diet was collected using the Block Food Frequency Questionnaire, and diet quality was assessed using the Alternative Healthy Eating Index-2010 (AHEI

SUBMITTER: Wen X 

PROVIDER: S-EPMC11347812 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature