Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach.

ABSTRACT:

Background and objectives

The neurodevelopment of the offspring is suggested to be influenced by the maternal immune system's responses throughout pregnancy, which in turn is also vulnerable to maternal psychosocial stress conditions. Therefore, our main goal was to investigate whether maternal peripheral immunological biomarkers (IB) during two stages of gestation are associated with distinct neurodevelopmental trajectories in the first two years of life. As a second goal, we also explored the association between maternal distal (childhood) and proximal (gestation) stressful experiences and the immunological markers assessed during pregnancy.

Methods

Maternal childhood trauma, depressive and anxiety symptoms, and peripheral IB (IFNγ, IL-10, IL1β, IL6, IL8, TNFα, EGF, IL13,

SUBMITTER: Euclydes V 

PROVIDER: S-EPMC11347843 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature