The immune factors involved in the rapid clearance of bacteria from the midgut of the tick <i>Ixodes ricinus</i>.

ABSTRACT: Ticks are obligate hematophagous arthropods that transmit a wide range of pathogens to humans as well as wild and domestic animals. They also harbor a non-pathogenic microbiota, although our previous study has shown that the diverse bacterial microbiome in the midgut of Ixodes ricinus is quantitatively poor and lacks a core. In artificial infections by capillary feeding of ticks with two model bacteria (Gram-positive Micrococcus luteus and Gram-negative Pantoea sp.), rapid clearance of these microbes from the midgut was observed, indicating the presence of active immune mechanisms in this organ. In the current study, RNA-seq analysis was performed on the midgut of I. ricinus females inoculated with either M. luteus or Pantoea sp. or with sterile wa

SUBMITTER: Guizzo MG 

PROVIDER: S-EPMC11347951 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature