Claudin and transmembrane receptor protein gene expressions are reversely correlated in peritumoral brain edema.

ABSTRACT:

Introduction

Peritumoral brain edema (PTBE) has been widely reported with many brain tumors, especially with glioma. Since the blood-brain barrier (BBB) is essential for maintaining minimal permeability, any alteration in the interaction of BBB components, specifically in astrocytes and tight junctions (TJ), can result in disrupting the homeostasis of the BBB and making it severely leaky, which subsequently generates edema.

Objective

This study aimed to evaluate the functional gliovascular unit of the BBB by examining changes in the expression of claudin (CLDN) genes and the expression of transient receptor potential (TRP) membrane channels, additionally to define the correlation between their expressions. The evaluation was conducted using in vitro spheroid swelling models

SUBMITTER: Abuelrub A 

PROVIDER: S-EPMC11347986 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature