Contribution of intraflagellar transport to compartmentalization and maintenance of the photoreceptor cell.

ABSTRACT: The first steps of vision take place in the ciliary outer segment compartment of photoreceptor cells. The protein composition of outer segments is uniquely suited to perform this function. The most abundant among these proteins is the visual pigment, rhodopsin, whose outer segment trafficking involves intraflagellar transport (IFT). Here, we report three major findings from the analysis of mice in which ciliary transport was acutely impaired by conditional knockouts of IFT-B subunits. First, we demonstrate the existence of a sorting mechanism whereby mislocalized rhodopsin is recruited to and concentrated in extracellular vesicles prior to their release, presumably to protect the cell from adverse effects of protein mislocalization. Second, reducing rhodopsin expression significantly delay

SUBMITTER: Lewis TR 

PROVIDER: S-EPMC11348033 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature