Cellular Energy Cycle Mediates an Advection-Like Forward Cell Flow to Support Collective Invasion.

ABSTRACT: Collective cell migration is a model for nonequilibrium biological dynamics, which is important for morphogenesis, pattern formation, and cancer metastasis. The current understanding of cellular collective dynamics is based primarily on cells moving within a 2D epithelial monolayer. However, solid tumors often invade surrounding tissues in the form of a stream-like 3D structure, and how biophysical cues are integrated at the cellular level to give rise to this collective streaming remains unclear. Here, it is shown that cell cycle-mediated bioenergetics drive a forward advective flow of cells and energy to the front to support 3D collective invasion. The cell division cycle mediates a corresponding energy cycle such that cellular adenosine triphosphate (ATP) energy peaks just before divisi

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11348062 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature