Injectable biodegradable microcarriers for iPSC expansion and cardiomyocyte differentiation.

ABSTRACT: Cell therapy is a potential novel treatment for cardiac regeneration and numerous studies have attempted to transplant cells to regenerate the myocardium lost during myocardial infarction. To date, only minimal improvements to cardiac function have been reported. This is likely to be the result of low cell retention and survival following transplantation. This study aimed to improve the delivery and engraftment of viable cells by using an injectable microcarrier that provides an implantable, biodegradable substrate for attachment and growth of cardiomyocytes derived from induced pluripotent stem cells (iPSC). We describe the fabrication and characterisation of Thermally Induced Phase Separation (TIPS) microcarriers and their surface modification to enable iPSC-derived cardiomyocyte attachm

SUBMITTER: Bettini A 

PROVIDER: S-EPMC11348074 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature