Integration of Functional Human Auditory Neural Circuits Based on a 3D Carbon Nanotube System.

ABSTRACT: The physiological interactions between the peripheral and central auditory systems are crucial for auditory information transmission and perception, while reliable models for auditory neural circuits are currently lacking. To address this issue, mouse and human neural pathways are generated by utilizing a carbon nanotube nanofiber system. The super-aligned pattern of the scaffold renders the axons of the bipolar and multipolar neurons extending in a parallel direction. In addition, the electrical conductivity of the scaffold maintains the electrophysiological activity of the primary mouse auditory neurons. The mouse and human primary neurons from peripheral and central auditory units in the system are then co-cultured and showed that the two kinds of neurons form synaptic connections. More

SUBMITTER: Lou Y 

PROVIDER: S-EPMC11348147 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature