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Pharmacochemical Study of Multitarget Amino Acids’ Hybrids: Design, Synthesis, In vitro, and In silico Studies

ABSTRACT:

Introduction

Neuro-inflammation is a complex phenomenon resulting in several disorders.

SUBMITTER: Fotopoulos I

PROVIDER: S-EPMC11348465 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Pharmacochemical Study of Multitarget Amino Acids' Hybrids: Design, Synthesis, <i>In vitro</i>, and <i>In silico</i> Studies.

Fotopoulos Ioannis I Pontiki Eleni E Hadjipavlou-Litina Dimitra D

Medicinal chemistry (Shariqah (United Arab Emirates)) 20240101 7

<h4>Introduction</h4>Neuro-inflammation is a complex phenomenon resulting in several disorders. ALOX-5, COX-2, pro-inflammatory enzymes, and amino acid neurotransmitters are tightly correlated to neuro-inflammatory pathologies. Developing drugs that interfere with these targets will offer treatment for various diseases.<h4>Objective</h4>Herein, we extend our previous research by synthesizing a series of multitarget hybrids of cinnamic acids with amino acids recognized as neurotransmitters.<h4>Me ...[more]

PMID: 38347768

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