The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast.

ABSTRACT:

Background

Human hexokinase 2 (HK2) plays an important role in regulating Warburg effect, which metabolizes glucose to lactate acid even in the presence of ample oxygen and provides intermediate metabolites to support cancer cell proliferation and tumor growth. HK2 overexpression has been observed in various types of cancers and targeting HK2-driven Warburg effect has been suggested as a potential cancer therapeutic strategy. Given that epigenetic enzymes utilize metabolic intermediates as substrates or co-factors to carry out post-translational modification of histones and nucleic acids modifications in cells, we hypothesized that altering HK2 expression could impact the epigenome and, consequently, chromatin stability in yeast. To test this hypothesis, we established genetic mode

SUBMITTER: Karri S 

PROVIDER: S-EPMC11348520 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature