Identifying metabotypes of insulin resistance severity in children with metabolic syndrome.

ABSTRACT:

Background

Insulin resistance is a frequent precursor of typical obesity and metabolic syndrome complications. However, accurate diagnosis remains elusive because of its pathophysiological complexity and heterogeneity. Herein, we have explored the utility of insulin secretion dynamics in response to an oral glucose tolerance test as a surrogate marker to identify distinct metabotypes of disease severity.

Methods

The study population consisted of children with obesity and insulin resistance, stratified according to the post-challenge insulin peak timing (i.e., early, middle, and late peak), from whom fasting and postprandial plasma and erythrocytes were collected for metabolomics analysis.

Results

Children with late insulin peak manifested worse cardiometabolic health

SUBMITTER: Gonzalez-Dominguez A 

PROVIDER: S-EPMC11348533 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature