<i>In vivo</i> photopharmacological inhibition of hippocampal activity <i>via</i> multimodal probes - perspective and opening steps on experimental and computational challenges.

ABSTRACT: Neurological conditions such as epilepsy can have a significant impact on people's lives. Here, we discuss a new perspective for the study/treatment of these conditions using photopharmacology. A multimodal, intracranial implant that incorporates fluidic channels for localised drug delivery, electrodes for recording and stimulation, and a light source for photoswitching is used for in vivo administration and deactivation of a photoresponsive AMPA antagonist. We review current advancements in the relevant disciplines and show experimentally that the inhibition of seizure-like events induced in the hippocampus by electrical stimulation can be altered upon switching the drug with light. We discuss the interconnection of the drug's photopharmacological properties with the design of the

SUBMITTER: Gurke J 

PROVIDER: S-EPMC11348833 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature