Synthetic cation channel: reconstructing the ion permeation pathway of TRPA1 in an artificial system.

ABSTRACT: A novel artificial cation channel was developed by rebuilding the ion permeation pathway of the natural channel protein (TRPA1) in a synthetic system. This tubular molecule can effectively embed into lipid bilayers and form transmembrane channels, thereby mediating cation transport. Furthermore, due to its carboxyl-modified ion permeation pathway, the transport activity of this artificial channel can be modulated by the pH of the buffer solution.

SUBMITTER: Xin P 

PROVIDER: S-EPMC11348841 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature