In vitro and in silico studies of alpha glucosidase inhibition and antifungal activity of coffea canephora husk.

ABSTRACT: The coffea canephora husk, a protected agricultural crop, is abundant in Vietnam. Examining the effects of C. canephora husk compounds on α-glucosidase and antifungal drug activity was the primary objective of this research. A cholestane-type steroid, coffeacanol A (1), was extracted from the ethyl acetate extract. Three cholestane-type derivatives (2-4) and three additional known compounds (5-7) were separated, and we used a variety of chromatographic techniques to identify a total of six substances. We used NMR to determine the chemical structures of these substances. Extensive HR-MS-ESI analysis and NMR experimental data were used to confirm the structure of the novel metabolite (1). The cholestane-type steroid was initially discovered in the Coffea canephora husk,

SUBMITTER: Mai TTN 

PROVIDER: S-EPMC11348856 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature