Liver function and portal-systemic shunting quantified by the oral cholate challenge test and risk for large oesophageal varices.

ABSTRACT:

Background

The quantitative HepQuant SHUNT test of liver function and physiology generates a disease severity index (DSI) that correlates with risk for clinical complications, such as large oesophageal varices (LEVs). A derivative test, HepQuant DuO, generates an equivalent DSI and simplifies testing by requiring only oral administration of the test solution and two blood samples at 20 and 60 min.

Aims

Since the DSIs measured from DuO and SHUNT are equivalent, we compared the diagnostic performance for large oesophageal varices (LEVs) between the DSIs measured from DuO and SHUNT tests.

Methods

This study combined the data from two prospectively conducted US studies: HALT-C and SHUNT-V. A total of 455 subjects underwent both the SHUNT test and esophagogastroduodenoscop

SUBMITTER: Hassanein T 

PROVIDER: S-EPMC11348877 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature