Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition.

ABSTRACT:

Objective

Stress exposures may have a differential impact on risk and resilience for depression depending on their timing across development. We sought to determine whether adverse childhood experiences (ACEs) and their onset with respect to puberty contribute to the increased risk observed in first-episode major depressive disorder (MDD) during the menopause transition.

Methods

Participants were from the Penn Ovarian Aging Study cohort, which is composed of women from Philadelphia County, Pennsylvania, who underwent behavioral, cognitive, and endocrine evaluations approximately yearly from 1996 to 2012 and completed the Adverse Childhood Experiences Questionnaire at study end point (n = 243). ACEs that first occurred 2 or more years before menarche were considered prepubert

SUBMITTER: Epperson CN 

PROVIDER: S-EPMC11348890 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature