TagP, a PAAR-domain containing protein, plays roles in the fitness and virulence of Acinetobacter baumannii.

ABSTRACT:

Background

Type VI secretion system (T6SS) is widely present in Gram-negative bacteria and directly mediates antagonistic prokaryote interactions. PAAR (proline-alanine-alanine-arginine repeats) proteins have been proven essential for T6SS-mediated secretion and target cell killing. Although PAAR proteins are commonly found in A. baumannii, their biological functions are not fully disclosed yet. In this study, we investigated the functions of a PAAR protein termed TagP (T6SS-associated-gene PAAR), encoded by the gene ACX60_RS09070 outside the core T6SS locus of A. baumannii strain ATCC 17978.

Methods

In this study, tagP null and complement A. baumannii ATCC 17978 strains were constructed. The influence of TagP on T6SS function was investigated thr

SUBMITTER: Li Y 

PROVIDER: S-EPMC11348943 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature