Glymphatic System Dysfunction Underlying Schizophrenia Is Associated With Cognitive Impairment.

ABSTRACT:

Background and hypothesis

Despite the well-documented structural and functional brain changes in schizophrenia, the potential role of glymphatic dysfunction remains largely unexplored. This study investigates the glymphatic system's function in schizophrenia, utilizing diffusion tensor imaging (DTI) to analyze water diffusion along the perivascular space (ALPS), and examines its correlation with clinical symptoms.

Study design

A cohort consisting of 43 people with schizophrenia and 108 healthy controls was examined. We quantified water diffusion metrics along the x-, y-, and z-axis in both projection and association fibers to derive the DTI-ALPS index, a proxy for glymphatic activity. The differences in the ALPS index between groups were analyzed using a 2-way ANCOVA control

SUBMITTER: Tu Y 

PROVIDER: S-EPMC11349007 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature