Corollary Discharge Dysfunction as a Possible Substrate of Anomalous Self-experiences in Schizophrenia.

ABSTRACT:

Background and hypothesis

Corollary discharge mechanism suppresses the conscious auditory sensory perception of self-generated speech and attenuates electrophysiological markers such as the auditory N1 Event-Related Potential (ERP) during Electroencephalographic (EEG) recordings. This phenomenon contributes to self-identification and seems to be altered in people with schizophrenia. Therefore, its alteration could be related to the anomalous self-experiences (ASEs) frequently found in these patients.

Study design

To analyze corollary discharge dysfunction as a possible substrate of ASEs, we recorded EEG ERP from 43 participants with schizophrenia and 43 healthy controls and scored ASEs with the 'Inventory of Psychotic-Like Anomalous Self-Experiences' (IPASE). Positive and ne

SUBMITTER: Beno-Ruiz-de-la-Sierra RM 

PROVIDER: S-EPMC11349017 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature