Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum.

ABSTRACT:

Background and hypothesis

Abnormal thalamic nuclei volumes and their link to cognitive impairments have been observed in schizophrenia. However, whether and how this finding extends to the schizophrenia spectrum is unknown. We hypothesized a distinct pattern of aberrant thalamic nuclei volume across the spectrum and examined its potential associations with cognitive symptoms.

Study design

We performed a FreeSurfer-based volumetry of T1-weighted brain MRIs from 137 healthy controls, 66 at-risk mental state (ARMS) subjects, 89 first-episode psychosis (FEP) individuals, and 126 patients with schizophrenia to estimate thalamic nuclei volumes of six nuclei groups (anterior, lateral, ventral, intralaminar, medial, and pulvinar). We used linear regression models, controlling for se

SUBMITTER: Thalhammer M 

PROVIDER: S-EPMC11349018 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature