Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction.

ABSTRACT:

Background

Exosome therapy shows potential for cardiac repair after injury. However, intrinsic challenges such as short half-life and lack of clear targets hinder the clinical feasibility. Here, we report a noninvasive and repeatable method for exosome delivery through inhalation after myocardial infarction (MI), which we called stem cell-derived exosome nebulization therapy (SCENT).

Methods

Stem cell-derived exosomes were characterized for size distribution and surface markers. C57BL/6 mice with MI model received exosome inhalation treatment through a nebulizer for 7 consecutive days. Echocardiographies were performed to monitor cardiac function after SCENT, and histological analysis helped with the investigation of myocardial repair. Single-cell RNA sequencing of the whole

SUBMITTER: Li J 

PROVIDER: S-EPMC11349039 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature