Is there a causal relationship between resistin levels and bone mineral density, fracture occurrence? A mendelian randomization study.

ABSTRACT:

Background

In a great many of observational studies, whether there is a relevance of resistin levels on bone mineral density (BMD) and fracture occurrence has been inconsistently reported, and the causality is unclear.

Methods

We aim to assess the resistin levels on BMD and fracture occurrence within a Mendelian randomization (MR) analysis. Exposure and outcome data were derived from the Integrative Epidemiology Unit (IEU) Open genome wide association studies (GWAS) database. Screening of instrumental variables (IVs) was performed subject to conditions of relevance, exclusivity, and independence. Inverse variance weighting (IVW) was our primary method for MR analysis based on harmonized data. Weighted median and MR-Egger were chosen to evaluate the robustness of the results

SUBMITTER: Xu T 

PROVIDER: S-EPMC11349205 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature