Interrogating basal ganglia circuit function in people with Parkinson's disease and dystonia.

ABSTRACT:

Background

The dichotomy between the hypo- versus hyperkinetic nature of Parkinson's disease (PD) and dystonia, respectively, is thought to be reflected in the underlying basal ganglia pathophysiology. In this study, we investigated differences in globus pallidus internus (GPi) neuronal activity, and short- and long-term plasticity of direct pathway projections.

Methods

Using microelectrode recording data collected from the GPi during deep brain stimulation surgery, we compared neuronal spiketrain features between people with PD and those with dystonia, as well as correlated neuronal features with respective clinical scores. Additionally, we characterized and compared readouts of short- and long-term synaptic plasticity using measures of inhibitory evoked field potentials.

SUBMITTER: Sumarac S 

PROVIDER: S-EPMC11349293 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature