Default Mode and Frontoparietal Network Dynamics: Associations with Familial Risk for Depression and Stress Sensitivity.

ABSTRACT:

Background

Major Depressive Disorder (MDD) is associated with alterations within the default mode (DMN) and frontoparietal (FPN) networks. However, it is unclear whether changes in these networks occur prior to onset in youth at high familial risk for MDD or are a consequence of MDD. Moreover, studies examining premorbid MDD vulnerability markers have focused on static rather than dynamic network properties, which could further elucidate DMN-FPN imbalances linked to MDD risk.

Methods

Eighty-nine unaffected 12-14-year-old adolescents both with (n = 27) and without (n = 62) a maternal history of MDD completed a resting state functional magnetic resonance imaging scan and self-report assessments of depressive symptoms and perceived stress at baseline and every thr

SUBMITTER: Belleau EL 

PROVIDER: S-EPMC11349319 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature