Prevalence, trends, and characteristics of trials investigating local therapy in contemporary phase 3 clinical cancer research.

ABSTRACT:

Background

Although most patients with cancer are treated with local therapy (LT), the proportion of late-phase clinical trials investigating local therapeutic interventions is unknown. The purpose of this study was to determine the proportion, characteristics, and trends of phase 3 cancer clinical trials assessing the therapeutic value of LT over time.

Methods

This was a cross-sectional analysis of interventional randomized controlled trials in oncology published from 2002 through 2020 and registered on ClinicalTrials.gov. Trends and characteristics of LT trials were compared to all other trials.

Results

Of 1877 trials screened, 794 trials enrolling 584,347 patients met inclusion criteria. A total of 27 trials (3%) included a primary randomization assessing LT compar

SUBMITTER: Sherry AD 

PROVIDER: S-EPMC11349322 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature