The impact of metabolic syndrome on the cerebral cortex: a Mendelian randomization study.

ABSTRACT: Metabolic syndrome exhibits associations with diverse neurological disorders, and its potential influence on the cerebral cortex may be one of the many potential factors contributing to these adverse outcomes. In this study, we aimed to investigate the causal relationship between metabolic syndrome and changes in cerebral cortex structure using Mendelian randomization analysis. Genome-wide association study data for the 5 components of metabolic syndrome were obtained from individuals of European descent in the UK Biobank. Genome-wide association study data for 34 known cortical functional regions were sourced from the ENIGMA Consortium. Data on Alzheimer's disease, major depression, and anxiety disorder were obtained from the IEU Open genome-wide association study database. The causal lin

SUBMITTER: Zhang P 

PROVIDER: S-EPMC11349429 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature