Clinicopathological characteristics of pediatric ANCA-associated glomerulonephritis.

ABSTRACT:

Background

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and glomerulonephritis is uncommon in children. We sought to characterize the histological and clinical features of the disease and report on risk factors for adverse outcomes in a pediatric cohort.

Methods

Retrospective single-center cohort of all pediatric (< 20 years) patients diagnosed with ANCA-associated glomerulonephritis (AAGN) by kidney biopsy between 2002 and 2022 at Johns Hopkins University. Histological and clinical features were extracted from the medical record. Clinical, laboratory, and histological findings were analyzed to determine the association with kidney failure (KF) and/or death.

Results

A total of 17 patients were identified (GPA n = 7, MPA = 10) with a median age of

SUBMITTER: Charnaya O 

PROVIDER: S-EPMC11349454 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature