Preservation of vision by transpalpebral electrical stimulation in mice with inherited retinal degeneration.

ABSTRACT:

Introduction

The potential neuroprotective and regenerative properties of electrical stimulation (ES) were studied in rhodopsin knockout mice (Rho ^-/- ), a murine model of inherited retinal degeneration. The study focused on assessing the impact of varying ES frequencies on visual functions and photoreceptor cell survival in Rho ^-/- mice.

Methods

To elucidate the impact of electrical stimulation on cone survival, Rho ^-/- mice received either sham or transpalpebral ES using biphasic ramp or rectangular waveforms at 100 µA amplitude, starting at six weeks of age. The treatment duration spanned from one to three weeks. The optimal treatment frequency of ES sessions was determined by applying ES every one

SUBMITTER: Gunes K 

PROVIDER: S-EPMC11349514 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature