Causal relationships between gut microbiota, immune cell, and Henoch-Schonlein Purpura: a two-step, two-sample Mendelian randomization study.

ABSTRACT:

Background

Regulating the immune system is a crucial measure of gut microbiota (GM) that influences the development of diseases. The causal role of GM on Henoch-Schönlein Purpura (HSP) and whether it can be mediated by immune cells is still unknown.

Methods

We performed a two-sample Mendelian randomization study using an inverse variance weighted (IVW) method to examine the causal role of GM on HSP and the mediation effect of immune cells between the association of GM and HSP.

Results

We demonstrated the causal relationships between 14 axas and 6 pathways with HSP. Additionally, we identified 9 immune cell characteristics associated with HSP. Importantly, through mediation MR analysis, we identified several immune cell characteristics that mediate the impact of GM on

SUBMITTER: Liang T 

PROVIDER: S-EPMC11349531 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature