Applying an ELSI lens to real-world data and novel genomic insights for personalized mental healthcare.

ABSTRACT: Improving the understanding of the complex relationship between genetic predispositions, environmental influences, and sociocultural factors in the development and progression of mental illness is crucial for optimizing treatment efficacy and addressing longstanding health disparities. This paper discusses the ethical, legal, and social implications (ELSI) of recent advancements in biomedical research, particularly in genome-wide association studies (GWAS), phenome-wide association studies (PheWAS), and genome-wide environment interaction studies (GWEIS). Despite recent scientific progresses, challenges such as inadequate study methodology (e.g., correlational studies) and lack of diversity within study samples persist. Recent discoveries of several genetic variants of diseases, could augm

SUBMITTER: Hendricks-Sturrup RM 

PROVIDER: S-EPMC11349570 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature