A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis.

ABSTRACT: Orchestrating complex behaviors, such as approaching and consuming food, is critical for survival. In addition to hypothalamus neuronal circuits, the nucleus accumbens (NAc) also controls appetite and satiety. However, specific neuronal subtypes of the NAc that are involved and how the humoral and neuronal signals coordinate to regulate feeding remain incompletely understood. Here we decipher the spatial diversity of neuron subtypes of the NAc shell (NAcSh) and define a dopamine receptor D1-expressing and Serpinb2-expressing subtype controlling food consumption in male mice. Chemogenetics and optogenetics-mediated regulation of Serpinb2⁺ neurons bidirectionally regulate food seeking and consumption specifically. Circuitry stimulation reveals that the NAcSh^Serpinb2→LH<

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11349581 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature