Albuterol Delivery via In-Line Intrapulmonary Percussive Ventilation Superimposed on Invasive Ventilation in an Adult Lung Model.

ABSTRACT:

Background

Intrapulmonary percussive ventilation (IPV) is frequently used for airway clearance, together with delivery of aerosolized medications. Drug delivery via IPV alone increases with decreasing percussion frequency and correlates with tidal volume ([Formula: see text]), whereas drug delivery via IPV during invasive ventilation is not well characterized. We hypothesized that drug delivery via IPV-invasive ventilation would differ from IPV alone due to control of ventilation by invasive ventilation.

Methods

An adult ventilator circuit was used for IPV-invasive ventilation. A normal or a diseased lung model was configured to airway resistance of 5 cm H₂O/L/s and lung compliance of 100 mL/cm H₂O or to airway resistance of 20 cm H₂O/L/s and

SUBMITTER: Karashima T 

PROVIDER: S-EPMC11349587 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature