Male infertility risk and plasma lipidome: a Mendelian randomization study.

ABSTRACT:

Background

In recent years, the decline in sperm quality in men has become a global trend. There is a close relationship between sperm quality and pregnancy outcome. There is a large body of literature supporting the role of plasma lipidome in male infertility, while the complex mechanisms between them and male infertility are still less clear. Systematic study of the causal relationship between plasma lipidome and MI can help to provide new therapeutic ideas and targets for male infertility.

Methods

In this study, we used a two-sample Mendelian randomization analysis based on Genome-wide association studies pooled data of 179 causal relationships between plasma lipidome and male infertility. We used employed the inverse variance weighted method as the main analysis to asses

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11349629 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature