Causal link between metabolic related factors and osteoarthritis: a Mendelian randomization investigation.

ABSTRACT:

Introduction

Metabolic syndrome (MetS) is significantly associated with osteoarthritis (OA), especially in MetS patients with blood glucose abnormalities, such as elevated fasting blood glucose (FG), which may increase OA risk. Dietary modifications, especially the intake of polyunsaturated fatty acids (PUFAs), are regarded as a potential means of preventing MetS and its complications. However, regarding the effects of FG, Omega-3s, and Omega-6s on OA, the research conclusions are conflicting, which is attributed to the complexity of the pathogenesis of OA. Therefore, it is imperative to thoroughly evaluate multiple factors to fully understand their role in OA, which needs further exploration and clarification.

Methods

Two-sample univariable Mendelian randomization (UVMR) an

SUBMITTER: Li K 

PROVIDER: S-EPMC11349640 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature