Papillary Thyroid Carcinoma: Correlation Between Molecular and Clinical Features.

ABSTRACT:

Background

Thyroid cancer is prevalent worldwide, including in China, where its incidence is on the rise. Papillary thyroid carcinoma (PTC) is the predominant subtype. Investigating the relationship between clinical data associated with PTC and gene mutations is crucial for improving detection and treatment.

Patients and methods

We collected samples and associated clinical data from 700 PTC patients at Shanxi Provincial People's Hospital. Using a panel of 57 genes linked to thyroid cancer, we sequenced the samples to determine the mutation frequency of thyroid cancer-associated genes in PTC. We further analyzed the correlation between gene variants and clinical information.

Results

The mean age of patients in this study was 42.5 years. Females predominated, comprising

SUBMITTER: Wang Q 

PROVIDER: S-EPMC11349796 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature