Clinical Efficacy and Safety of Anti-Obesity Medications Among Adult East Asian People with Obesity: A Systematic Literature Review and Indirect Treatment Comparison.

ABSTRACT:

Introduction

The prevalence of obesity has increased worldwide over the past decades. Regional variations exist in the relationship between body mass index (BMI), body fat, and health risks: Asians typically have a lower BMI than people of European descent, but a higher risk of obesity-related comorbidities. However, there is a paucity of evidence for anti-obesity medications (AOMs) in East Asian populations. In this study, we aimed to systematically review evidence regarding the safety and efficacy of AOMs among adults with obesity disease in East Asia, and to assess the feasibility of conducting an indirect treatment comparison (ITC) between the semaglutide and mazindol trials.

Methods

The Embase, MEDLINE, and ICHUSHI databases were searched via the Ovid SP platform for ra

SUBMITTER: Yokote K 

PROVIDER: S-EPMC11349800 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature