The extent of kidney involvement in paediatric tuberous sclerosis complex.

ABSTRACT:

Background

Tuberous sclerosis (TSC)-associated kidney disease is a leading cause of mortality in adults with TSC. This study aimed to understand TSC features in children, particularly kidney involvement, to inform clinical care for this specific group.

Methods

This retrospective cohort study included all paediatric (< 19 years) TSC cases at a large tertiary paediatric nephrology centre. Relevant data were collected from patients' records, statistical analyses were performed to identify associations between variables, survival probabilities were estimated with Kaplan‒Meier curves, and log-rank tests were conducted to assess survival differences among genetic mutations.

Results

A total of 182 children with TSC were included. Among the 145 children with available kidney

SUBMITTER: Limavady A 

PROVIDER: S-EPMC11349837 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature