Regional impact of multidrug-resistant organism prevention bundles implemented by facility type: A modeling study.

ABSTRACT:

Background

Emerging multidrug-resistant organisms (MDROs), such as carbapenem-resistant Enterobacterales (CRE), can spread rapidly in a region. Facilities that care for high-acuity patients with longer stays may have a disproportionate impact on this spread.

Objective

We assessed the impact of implementing preventive interventions, directed at a subset of facilities, on regional prevalence.

Methods

We developed a deterministic compartmental model, parametrized using CRE and patient transfer data. The model included the community and healthcare facilities within a US state. Individuals may be either susceptible or infectious with CRE. Individuals determined to be infectious through admission screening, periodic prevalence surveys (PPSs), or interfacility communication

SUBMITTER: Cincotta SE 

PROVIDER: S-EPMC11349925 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature