Deficiency of interleukin-1 receptor antagonist in mice differentially affects bone properties under different genomic backgrounds.

ABSTRACT: When IL-1 receptor antagonist (IL-1rn) is knocked out, mice have shown strain background dependent and major QTL regulated susceptibility to spontaneously inflammatory arthritis disease (SAD). The impact on bone properties resulting from the interactions of IL-1rn, genomic background strains, and the QTL locus, is unknown. Bone properties in the four specifically bred mouse strains with mutation of IL-1rn and variations in genomic components were investigated with high-resolution MicroCT and genomic analytical tools. Two congenic mouse strains were also measured to evaluate the influence on bone properties by a QTL in the region in chromosome 1. Our results reveal that several bone phenotypes, including bone mineral density (BMD), bone volume, tibial length, and cortical thickness of the t

SUBMITTER: Dong W 

PROVIDER: S-EPMC11349940 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature