Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function.

ABSTRACT:

Introduction

Higher neuroticism might be associated with dementia risk. Here we investigated modification by genetic predisposition to dementia, mediation by mental health and vascular conditions, neuroimaging outcomes, and cognitive function.

Methods

Cox proportional-hazards models were used to assess the association between neuroticism score and incident dementia over up to 15 years in 1,74,164 participants. Cross-sectional analyses on dementia-related neuroimaging outcomes and cognitive function were conducted in 39,459 dementia-free participants.

Results

Higher neuroticism was associated with an 11% higher risk of incident dementia, especially vascular dementia (15% higher risk), regardless of genetic predisposition to dementia. Mental and vascular conditions medi

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11350007 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature