Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets.

ABSTRACT:

Introduction

Vervets are non-human primates that share high genetic homology with humans and develop amyloid beta (Aβ) pathology with aging. We expand current knowledge by examining Aβ pathology, aging, cognition, and biomarker proteomics.

Methods

Amyloid immunoreactivity in the frontal cortex and temporal cortex/hippocampal regions from archived vervet brain samples ranging from young adulthood to old age was quantified. We also obtained cognitive scores, plasma samples, and cerebrospinal fluid (CSF) samples in additional animals. Plasma and CSF proteins were quantified with platforms utilizing human antibodies.

Results

We found age-related increases in Aβ deposition in both brain regions. Bioinformatic analyses assessed associations between biomarkers and age, sex,

SUBMITTER: Varma C 

PROVIDER: S-EPMC11350037 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature